Motif ID: RXR{A,B,G}.p2

Z-value: 1.272


Transcription factors associated with RXR{A,B,G}.p2:

Gene SymbolEntrez IDGene Name
RXRA 6256 retinoid X receptor, alpha
RXRB 6257 retinoid X receptor, beta
RXRG 6258 retinoid X receptor, gamma



Activity profile for motif RXR{A,B,G}.p2.

activity profile for motif RXR{A,B,G}.p2


Sorted Z-values histogram for motif RXR{A,B,G}.p2

Sorted Z-values for motif RXR{A,B,G}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RXR{A,B,G}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_18081968 3.131 NM_002688
SEPT5
septin 5
chr6_+_43846372 2.604 VEGFA
vascular endothelial growth factor A
chr6_+_43845915 2.188 NM_001025366
NM_001025367
NM_001025368
NM_001025369
NM_001025370
NM_001033756
NM_001171622
NM_001171623
NM_001171624
NM_001171625
NM_001171626
NM_001171627
NM_001171628
NM_001171629
NM_001171630
NM_003376
VEGFA















vascular endothelial growth factor A















chr22_+_18085891 2.173 SEPT5
septin 5
chr22_+_18085990 2.131 SEPT5-GP1BB
SEPT5
SEPT5-GP1BB read-through transcript
septin 5
chr6_+_43845875 1.911 VEGFA
vascular endothelial growth factor A
chr6_+_43846155 1.816 VEGFA
vascular endothelial growth factor A
chr9_-_101621964 1.781


chr18_+_75261231 1.674 NM_172387
NM_172389
NFATC1

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

chr20_+_60558369 1.623 C20orf166
chromosome 20 open reading frame 166
chr6_+_43846735 1.621 VEGFA
vascular endothelial growth factor A
chr20_-_61933012 1.611 ZBTB46
zinc finger and BTB domain containing 46
chr1_+_9571518 1.526 NM_001010866
NM_001130924
TMEM201

transmembrane protein 201

chr22_+_48966394 1.509 TRABD
TraB domain containing
chr17_+_7125702 1.473 NM_001042
SLC2A4
solute carrier family 2 (facilitated glucose transporter), member 4
chr11_-_75595098 1.397 NM_004626
WNT11
wingless-type MMTV integration site family, member 11
chr17_+_34115383 1.312 NM_005937
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr5_+_139040479 1.293 CXXC5
CXXC finger protein 5
chr22_+_48966480 1.273 NM_025204
TRABD
TraB domain containing
chr1_-_38285033 1.266 NM_002699
POU3F1
POU class 3 homeobox 1
chr12_-_50871953 1.220 NM_001081492
NM_182507
KRT80

keratin 80

chr16_-_84342129 1.219 NM_206967
C16orf74
chromosome 16 open reading frame 74
chr22_+_21742727 1.210 GNAZ
guanine nucleotide binding protein (G protein), alpha z polypeptide
chr17_+_35751796 1.195 NM_001024809
RARA
retinoic acid receptor, alpha
chr22_+_21742364 1.192 NM_002073
GNAZ
guanine nucleotide binding protein (G protein), alpha z polypeptide
chr22_+_28446288 1.186 NM_182527
CABP7
calcium binding protein 7
chr22_+_22703107 1.178 NM_001144931
LOC391322
D-dopachrome tautomerase-like
chrX_+_152606945 1.135 NM_001142805
NM_005629
SLC6A8

solute carrier family 6 (neurotransmitter transporter, creatine), member 8

chr4_+_995609 1.127 NM_001004356
NM_001004358
FGFRL1

fibroblast growth factor receptor-like 1

chr19_+_1236766 1.124 NM_001405
EFNA2
ephrin-A2
chr2_+_232281491 1.086 PTMA
prothymosin, alpha
chr17_-_24302597 1.060 NM_001033561
NM_020889
PHF12

PHD finger protein 12

chr10_-_134605978 1.053 NM_173572
C10orf93
chromosome 10 open reading frame 93
chr4_+_995395 1.052 FGFRL1
fibroblast growth factor receptor-like 1
chr17_+_7151653 0.993 EIF5A
eukaryotic translation initiation factor 5A
chr19_+_55046229 0.991 PTOV1
prostate tumor overexpressed 1
chr16_+_2954217 0.956 NM_024507
NM_172229
KREMEN2

kringle containing transmembrane protein 2

chr7_+_2638108 0.947 NM_025250
TTYH3
tweety homolog 3 (Drosophila)
chr11_+_65162114 0.945 NM_006747
SIPA1
signal-induced proliferation-associated 1
chr1_-_33108876 0.944 NM_001171940
NM_153756
FNDC5

fibronectin type III domain containing 5

chr8_-_142586487 0.928 NM_207414
FLJ43860
FLJ43860 protein
chr6_+_41622267 0.923 FOXP4
forkhead box P4
chr1_+_1104939 0.921 NM_153254
TTLL10
tubulin tyrosine ligase-like family, member 10
chr19_+_3045528 0.912 GNA11
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
chr2_+_113709553 0.911 LOC654433
hypothetical LOC654433
chr17_-_76985538 0.906


chr17_+_70431964 0.889 NM_178160
OTOP2
otopetrin 2
chr7_-_126679540 0.888 NM_001127323
GRM8
glutamate receptor, metabotropic 8
chr22_+_17539198 0.883


chr20_-_56859352 0.879 GNAS-AS1
GNAS antisense RNA 1 (non-protein coding)
chr1_-_1840564 0.876 NM_178545
TMEM52
transmembrane protein 52
chr17_-_24302450 0.866 PHF12
PHD finger protein 12
chr7_-_5534252 0.861 ACTB
actin, beta
chr22_+_48740432 0.841 PIM3
pim-3 oncogene
chr5_+_169465478 0.840 NM_012188
NM_144769
FOXI1

forkhead box I1

chr20_-_61317891 0.827 NM_017798
YTHDF1
YTH domain family, member 1
chr16_-_69277355 0.826 NM_138383
MTSS1L
metastasis suppressor 1-like
chr7_+_2638156 0.826 TTYH3
tweety homolog 3 (Drosophila)
chr19_+_18391211 0.825 NM_001009998
NM_032627
SSBP4

single stranded DNA binding protein 4

chr19_+_18391423 0.809


chr7_-_5534737 0.801 ACTB
actin, beta
chr19_+_3457264 0.793 NM_016263
FZR1
fizzy/cell division cycle 20 related 1 (Drosophila)
chr11_-_63440891 0.790 NM_173587
RCOR2
REST corepressor 2
chr9_+_138900760 0.788 NM_021138
TRAF2
TNF receptor-associated factor 2
chr19_+_55046088 0.787 NM_017432
PTOV1
prostate tumor overexpressed 1
chr10_+_80740584 0.784 ZMIZ1
zinc finger, MIZ-type containing 1
chr12_+_47658502 0.784 NM_005430
WNT1
wingless-type MMTV integration site family, member 1
chr19_-_360138 0.766 NM_001136263
C2CD4C
C2 calcium-dependent domain containing 4C
chr1_-_2451543 0.761 NM_001010926
HES5
hairy and enhancer of split 5 (Drosophila)
chr6_+_33044353 0.748


chr22_+_29151651 0.746 NM_001003704
NM_016498
MTFP1

mitochondrial fission process 1

chr1_-_6468108 0.744 PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr19_+_18312365 0.735 NM_017712
FKBP8
PGPEP1
FK506 binding protein 8, 38kDa
pyroglutamyl-peptidase I
chr16_-_71650034 0.729 NM_001164766
ZFHX3
zinc finger homeobox 3
chr17_-_8643163 0.727 NM_152599
MFSD6L
major facilitator superfamily domain containing 6-like
chr22_+_19601723 0.726 CRKL
v-crk sarcoma virus CT10 oncogene homolog (avian)-like
chr19_+_540849 0.724 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr22_+_21318779 0.723 NM_199127
GGTLC2
gamma-glutamyltransferase light chain 2
chr19_-_55046117 0.719 LOC100506033
hypothetical LOC100506033
chr16_+_1949517 0.719 NM_004548
NDUFB10
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa
chr2_-_112907577 0.715 NM_001164463
RGPD8
RGPD5
RANBP2-like and GRIP domain containing 8
RANBP2-like and GRIP domain containing 5
chr19_+_18584666 0.711 NM_012109
TMEM59L
transmembrane protein 59-like
chr16_-_87244896 0.709 NM_000101
CYBA
cytochrome b-245, alpha polypeptide
chr9_+_139153409 0.709 NM_000832
NM_001185090
NM_001185091
NM_007327
NM_021569
GRIN1




glutamate receptor, ionotropic, N-methyl D-aspartate 1




chr17_-_76919068 0.708 NM_178520
TMEM105
transmembrane protein 105
chr22_+_19601721 0.708 CRKL
v-crk sarcoma virus CT10 oncogene homolog (avian)-like
chr19_-_54250808 0.705 NM_033142
CGB7
chorionic gonadotropin, beta polypeptide 7
chr7_-_4965270 0.705 NM_001100600
NM_198403
MMD2

monocyte to macrophage differentiation-associated 2

chr19_+_54872220 0.698 PRMT1
protein arginine methyltransferase 1
chr14_-_104706159 0.695 NM_002226
NM_145159
JAG2

jagged 2

chr3_-_50304706 0.689 NM_006764
IFRD2
interferon-related developmental regulator 2
chr17_+_7151368 0.686 NM_001970
EIF5A
eukaryotic translation initiation factor 5A
chr17_-_40401138 0.684 NM_006688
C1QL1
complement component 1, q subcomponent-like 1
chr12_+_110328126 0.683 NM_005475
SH2B3
SH2B adaptor protein 3
chr1_+_3597092 0.680 NM_001126240
NM_001126241
NM_001126242
TP73


tumor protein p73


chr1_+_27192719 0.679 NM_001013642
TRNP1
TMF1-regulated nuclear protein 1
chr9_+_132874324 0.679 NM_006059
LAMC3
laminin, gamma 3
chr22_-_17892001 0.678 CLDN5
claudin 5
chr16_+_87765661 0.676 NM_004933
CDH15
cadherin 15, type 1, M-cadherin (myotubule)
chr6_+_30018287 0.673 NM_002116
HLA-A
major histocompatibility complex, class I, A
chr19_+_54872304 0.673 NM_001536
NM_198318
PRMT1

protein arginine methyltransferase 1

chr6_+_41712907 0.672 MDFI
MyoD family inhibitor
chr16_+_2138608 0.666 NM_014353
RAB26
RAB26, member RAS oncogene family
chr19_+_7874701 0.666 MAP2K7
mitogen-activated protein kinase kinase 7
chr17_+_70343659 0.655 TMEM104
transmembrane protein 104
chr11_+_440260 0.655 NM_030783
PTDSS2
phosphatidylserine synthase 2
chr11_+_440346 0.653 PTDSS2
phosphatidylserine synthase 2
chr10_+_73703682 0.653 NM_019058
DDIT4
DNA-damage-inducible transcript 4
chr16_+_658158 0.653 RHOT2
ras homolog gene family, member T2
chr7_+_98994363 0.652 NM_001009958
NM_001009960
NM_001085367
NM_001085368
ZNF655



zinc finger protein 655



chr20_-_55718351 0.652 NM_020182
PMEPA1
prostate transmembrane protein, androgen induced 1
chr21_+_45649719 0.652


chr14_-_104705753 0.650 JAG2
jagged 2
chr22_-_17891777 0.650 CLDN5
claudin 5
chr17_+_45993338 0.649 NM_018896
NM_198376
NM_198377
NM_198378
NM_198379
NM_198380
NM_198382
NM_198383
NM_198384
NM_198385
NM_198386
NM_198387
NM_198388
NM_198396
NM_198397
CACNA1G














calcium channel, voltage-dependent, T type, alpha 1G subunit














chr7_+_100156358 0.648 NM_000799
EPO
erythropoietin
chr5_+_176786279 0.647 NM_001004105
NM_001004106
NM_002082
GRK6


G protein-coupled receptor kinase 6


chr11_-_45896144 0.643 NM_004813
NM_057174
PEX16

peroxisomal biogenesis factor 16

chr1_-_47468029 0.637 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr11_+_551449 0.636 NM_001143994
NM_003475
RASSF7

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

chr10_-_71002998 0.633 NM_020999
NEUROG3
neurogenin 3
chr4_-_2336328 0.633 NM_001172659
NM_001172660
ZFYVE28

zinc finger, FYVE domain containing 28

chr9_+_37640996 0.630 NM_014907
FRMPD1
FERM and PDZ domain containing 1
chr22_+_36384647 0.630 NM_020315
PDXP
pyridoxal (pyridoxine, vitamin B6) phosphatase
chr4_+_996251 0.629 NM_021923
FGFRL1
fibroblast growth factor receptor-like 1
chr17_-_45562112 0.628 NM_174920
SAMD14
sterile alpha motif domain containing 14
chr22_+_18485145 0.627 RANBP1
RAN binding protein 1
chr19_+_7874764 0.624 NM_145185
MAP2K7
mitogen-activated protein kinase kinase 7
chr20_+_62158882 0.624 NM_198723
TCEA2
transcription elongation factor A (SII), 2
chr1_+_46541913 0.623 NM_006004
UQCRH
ubiquinol-cytochrome c reductase hinge protein
chr5_+_139040242 0.622 CXXC5
CXXC finger protein 5
chr6_+_31059463 0.621 NM_001010909
MUC21
mucin 21, cell surface associated
chr4_-_8180278 0.618 ABLIM2
actin binding LIM protein family, member 2
chr1_+_158317967 0.615 NM_004983
KCNJ9
potassium inwardly-rectifying channel, subfamily J, member 9
chr16_+_658081 0.612 NM_138769
RHOT2
ras homolog gene family, member T2
chr1_-_46541595 0.611 LRRC41
leucine rich repeat containing 41
chr19_+_44308224 0.609 NM_001014831
NM_001014832
NM_001014834
NM_001014835
NM_005884
PAK4




p21 protein (Cdc42/Rac)-activated kinase 4




chr16_+_29725665 0.609


chr22_+_20068039 0.609 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr16_+_68765428 0.606 NM_173619
CLEC18C
CLEC18A
CLEC18B
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
C-type lectin domain family 18, member B
chr4_-_154929657 0.606 NM_003013
SFRP2
secreted frizzled-related protein 2
chr1_-_46541560 0.606


chr19_+_935316 0.605 NM_024100
WDR18
WD repeat domain 18
chr22_+_18485095 0.604 RANBP1
RAN binding protein 1
chr6_+_31731647 0.603 NM_019101
APOM
apolipoprotein M
chr16_+_22733307 0.602 NM_006043
HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr16_+_1299674 0.602 UBE2I
ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)
chr6_-_150431864 0.601 NM_024518
ULBP3
UL16 binding protein 3
chr19_+_17047569 0.600 NM_001130065
NM_004145
MYO9B

myosin IXB

chr19_+_7874765 0.598 MAP2K7
mitogen-activated protein kinase kinase 7
chr1_-_46541525 0.595 LRRC41
leucine rich repeat containing 41
chr2_+_111206620 0.595 NM_001142807
ACOXL
acyl-CoA oxidase-like
chr10_-_80875097 0.593 NM_153367
ZCCHC24
zinc finger, CCHC domain containing 24
chr7_-_150283794 0.593 NM_172057
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr11_+_67563093 0.591 TCIRG1
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
chr1_-_46541618 0.590 NM_006369
LRRC41
leucine rich repeat containing 41
chr11_+_440408 0.588 PTDSS2
phosphatidylserine synthase 2
chr17_+_35046843 0.583 NM_001165937
NM_001165938
NM_006804
STARD3


StAR-related lipid transfer (START) domain containing 3


chr20_+_54637714 0.579 NM_003222
TFAP2C
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
chr6_+_30018265 0.579 HLA-A
major histocompatibility complex, class I, A
chr3_+_51680261 0.578 NM_001129884
NM_015926
TEX264

testis expressed 264

chr1_+_200584421 0.576 NM_001167857
NM_001167858
NM_002481
PPP1R12B


protein phosphatase 1, regulatory (inhibitor) subunit 12B


chr6_-_3172775 0.575 NM_178012
TUBB2B
tubulin, beta 2B
chr12_-_55920741 0.574 NM_020142
NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr19_+_7874762 0.573 MAP2K7
mitogen-activated protein kinase kinase 7
chr19_-_55046718 0.569 LOC100506033
hypothetical LOC100506033
chr19_+_7874774 0.568 MAP2K7
mitogen-activated protein kinase kinase 7
chr5_-_746413 0.568 NM_007030
TPPP
tubulin polymerization promoting protein
chr19_+_52451570 0.561 NM_015603
CCDC9
coiled-coil domain containing 9
chr6_+_31731667 0.561 APOM
apolipoprotein M
chr19_-_9908014 0.560 NM_058164
OLFM2
olfactomedin 2
chr19_+_1389410 0.559 RPS15
ribosomal protein S15
chr17_+_8132539 0.558 NM_001177801
NM_001177802
NM_016492
RANGRF


RAN guanine nucleotide release factor


chr11_+_72765318 0.557 NM_032871
RELT
RELT tumor necrosis factor receptor
chr16_+_1299693 0.555 UBE2I
ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)
chr1_-_201411533 0.550 NM_004997
MYBPH
myosin binding protein H
chr12_+_88268845 0.547 LOC100131490
hypothetical LOC100131490
chr2_+_220200530 0.547 NM_005070
NM_201574
SLC4A3

solute carrier family 4, anion exchanger, member 3

chr11_+_817584 0.544 NM_173584
EFCAB4A
EF-hand calcium binding domain 4A
chr16_-_29818334 0.544 SEZ6L2
seizure related 6 homolog (mouse)-like 2
chr20_+_44070946 0.542 NM_004994
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr4_-_658035 0.542 NM_007100
ATP5I
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
chr19_-_18409971 0.541 NM_001170938
NM_016368
ISYNA1

inositol-3-phosphate synthase 1

chr19_-_16494897 0.535 CHERP
calcium homeostasis endoplasmic reticulum protein
chr20_+_43996717 0.535 NM_022104
PCIF1
PDX1 C-terminal inhibiting factor 1
chr17_+_71097147 0.530 MYO15B
myosin XVB pseudogene
chr11_-_62136778 0.530 NM_153265
EML3
echinoderm microtubule associated protein like 3
chr16_+_2145810 0.528 TRAF7
TNF receptor-associated factor 7
chr9_-_130006309 0.528 NM_001131015
NM_012127
CIZ1

CDKN1A interacting zinc finger protein 1

chr1_+_205137410 0.527 NM_001185156
NM_001185157
NM_001185158
NM_006850
IL24



interleukin 24



chr19_+_17691302 0.524 NM_018174
MAP1S
microtubule-associated protein 1S
chr20_+_62164900 0.524 TCEA2
transcription elongation factor A (SII), 2
chr11_+_43920385 0.523 NM_001145033
C11orf96
chromosome 11 open reading frame 96
chr19_+_55579272 0.523 POLD1
polymerase (DNA directed), delta 1, catalytic subunit 125kDa
chr16_+_1299654 0.522 UBE2I
ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)
chr16_+_1299637 0.520 NM_003345
NM_194259
UBE2I

ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)

chr13_+_113369470 0.520 NM_002929
GRK1
G protein-coupled receptor kinase 1
chr2_+_95326753 0.520 NM_013434
KCNIP3
Kv channel interacting protein 3, calsenilin
chr19_+_52451642 0.519 CCDC9
coiled-coil domain containing 9
chr5_+_139040370 0.518 CXXC5
CXXC finger protein 5

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.38 1.56e-08 GO:0048522 positive regulation of cellular process
1.62 4.37e-08 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.34 1.05e-07 GO:0048518 positive regulation of biological process
1.86 1.07e-06 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.16 4.98e-06 GO:0050794 regulation of cellular process
1.14 7.55e-06 GO:0065007 biological regulation
1.89 3.66e-05 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.14 1.07e-04 GO:0050789 regulation of biological process
1.28 1.79e-04 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.60 1.93e-04 GO:0010628 positive regulation of gene expression
1.62 2.57e-04 GO:0045893 positive regulation of transcription, DNA-dependent
1.63 2.68e-04 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.61 5.34e-04 GO:0051172 negative regulation of nitrogen compound metabolic process
1.26 7.22e-04 GO:0051171 regulation of nitrogen compound metabolic process
1.24 8.04e-04 GO:0048856 anatomical structure development
1.71 1.09e-03 GO:0032583 regulation of gene-specific transcription
1.57 1.15e-03 GO:0051254 positive regulation of RNA metabolic process
1.28 1.35e-03 GO:0051252 regulation of RNA metabolic process
1.58 1.42e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.56 1.46e-03 GO:0031327 negative regulation of cellular biosynthetic process
1.57 1.51e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
1.28 1.53e-03 GO:0048519 negative regulation of biological process
1.36 1.67e-03 GO:0009653 anatomical structure morphogenesis
1.52 1.79e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
1.20 1.95e-03 GO:0032502 developmental process
1.08 2.37e-03 GO:0009987 cellular process
1.36 2.46e-03 GO:0009966 regulation of signal transduction
1.61 2.56e-03 GO:0051253 negative regulation of RNA metabolic process
1.54 2.59e-03 GO:0009890 negative regulation of biosynthetic process
1.24 2.64e-03 GO:0048731 system development
1.51 2.82e-03 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.53 2.83e-03 GO:0009790 embryo development
1.21 2.93e-03 GO:0007275 multicellular organismal development
1.26 2.93e-03 GO:2000112 regulation of cellular macromolecule biosynthetic process
2.15 3.03e-03 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
1.50 3.19e-03 GO:0051173 positive regulation of nitrogen compound metabolic process
1.61 3.25e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.28 3.73e-03 GO:0048523 negative regulation of cellular process
1.56 4.90e-03 GO:0010629 negative regulation of gene expression
1.27 5.85e-03 GO:0006355 regulation of transcription, DNA-dependent
1.24 5.86e-03 GO:0009889 regulation of biosynthetic process
1.39 6.05e-03 GO:0010604 positive regulation of macromolecule metabolic process
1.24 6.38e-03 GO:0031326 regulation of cellular biosynthetic process
1.78 6.62e-03 GO:0001501 skeletal system development
1.38 7.68e-03 GO:0031325 positive regulation of cellular metabolic process
1.25 7.77e-03 GO:0010556 regulation of macromolecule biosynthetic process
1.20 1.16e-02 GO:0080090 regulation of primary metabolic process
1.36 1.26e-02 GO:0009893 positive regulation of metabolic process
1.19 1.49e-02 GO:0031323 regulation of cellular metabolic process
1.43 1.99e-02 GO:0009891 positive regulation of biosynthetic process
1.43 1.99e-02 GO:0006351 transcription, DNA-dependent
1.44 2.03e-02 GO:0031328 positive regulation of cellular biosynthetic process
1.23 2.17e-02 GO:0010468 regulation of gene expression
1.41 2.48e-02 GO:0010605 negative regulation of macromolecule metabolic process
1.19 3.42e-02 GO:0051179 localization
1.27 3.49e-02 GO:0048583 regulation of response to stimulus
1.39 3.75e-02 GO:0009892 negative regulation of metabolic process
1.29 3.80e-02 GO:0023051 regulation of signaling
1.40 4.84e-02 GO:0031324 negative regulation of cellular metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.15 1.73e-04 GO:0044422 organelle part
1.15 2.98e-04 GO:0044446 intracellular organelle part
1.25 1.31e-03 GO:0031974 membrane-enclosed lumen
1.07 3.23e-03 GO:0044424 intracellular part
1.24 3.46e-03 GO:0043233 organelle lumen
1.06 6.67e-03 GO:0005622 intracellular
1.23 8.96e-03 GO:0070013 intracellular organelle lumen
1.09 9.26e-03 GO:0043231 intracellular membrane-bounded organelle
1.24 1.04e-02 GO:0044428 nuclear part
1.08 1.11e-02 GO:0043226 organelle
1.08 1.11e-02 GO:0043229 intracellular organelle
1.09 1.16e-02 GO:0043227 membrane-bounded organelle
1.25 1.96e-02 GO:0031981 nuclear lumen
1.67 2.28e-02 GO:0015629 actin cytoskeleton
1.58 4.71e-02 GO:0048471 perinuclear region of cytoplasm

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.75 5.33e-09 GO:0043565 sequence-specific DNA binding
1.59 2.92e-08 GO:0001071 nucleic acid binding transcription factor activity
1.59 2.92e-08 GO:0003700 sequence-specific DNA binding transcription factor activity
1.53 8.38e-07 GO:0030528 transcription regulator activity
1.13 5.60e-05 GO:0005515 protein binding
1.25 2.85e-03 GO:0003677 DNA binding
1.67 1.86e-02 GO:0016563 transcription activator activity